NCAMmediated

NCAMmediated refers to processes or interactions that are facilitated or carried out by Neural Cell Adhesion Molecules (NCAMs). NCAMs are a family of cell surface glycoproteins that play crucial roles in cell-cell and cell-extracellular matrix adhesion. They are particularly important in the nervous system, where they are involved in neuronal development, migration, differentiation, and synaptic plasticity.

NCAMmediated adhesion is typically calcium-independent and can be homophilic (NCAM binding to other NCAM molecules on adjacent cells) or heterophilic (NCAM binding to other molecules). This adhesion contributes to the formation and maintenance of neural circuits. Beyond adhesion, NCAMmediated signaling pathways are involved in regulating gene expression and downstream cellular events that influence neuronal survival, neurite outgrowth, and synaptogenesis.

Dysregulation of NCAMmediated processes has been implicated in various neurological disorders, including neurodevelopmental conditions and neurodegenerative diseases. Understanding NCAMmediated mechanisms provides insights into normal brain function and potential therapeutic targets for neurological conditions. The term NCAMmediated emphasizes the direct involvement of these specific adhesion molecules in the biological phenomena being described.