NAT5

NAT5, also known as N-acetyltransferase 5, is a human enzyme. It belongs to the N-acetyltransferase superfamily, which are enzymes involved in the transfer of an acetyl group to a substrate molecule. In humans, NAT5 is primarily known for its role in the metabolism of xenobiotics, which are foreign compounds that enter the body. Specifically, it has been implicated in the acetylation of various drugs and environmental toxins, contributing to their detoxification and elimination from the body. The enzyme utilizes acetyl-CoA as its acetyl donor. While the exact physiological substrates and functions of NAT5 are still areas of ongoing research, it is believed to play a role in cellular defense mechanisms. Genetic variations in the NAT5 gene have been investigated for potential associations with inter-individual differences in drug response and susceptibility to certain diseases. Further research is needed to fully elucidate the complete spectrum of NAT5 activity and its clinical significance.