NADNADPdependent
NADNADPdependent refers to enzymes that use either NAD+ (nicotinamide adenine dinucleotide) or NADP+ (nicotinamide adenine dinucleotide phosphate) as a cofactor in redox reactions. In many cases, enzymes are specific for one cofactor, but some display flexibility and can utilize both, depending on isoform, organism, or cellular conditions. The choice of cofactor has broad metabolic implications because NAD+/NADH and NADP+/NADPH participate in distinct cellular processes.
NAD+-dependent enzymes are typically associated with catabolic pathways that generate energy. They catalyze oxidation of substrates
Structural features governing cofactor specificity often involve the active site and cofactor-binding motifs. NADP+ differs from
Representative examples include NAD+-dependent lactate dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase, which participate in glycolytic energy production, and