Mikronukleustestit
Mikronukleustestit, also known as micronucleus tests, are biological assays used to assess the genotoxic potential of chemicals or environmental agents. These tests are based on the observation that micronuclei, which are small, circular structures of chromosomal material, can be formed in the cytoplasm of cells as a result of chromosomal damage. The micronucleus test is commonly used in in vitro and in vivo studies to evaluate the clastogenic and aneugenic properties of substances.
In the in vitro micronucleus test, cells from various tissues, such as peripheral blood lymphocytes or bone
In the in vivo micronucleus test, animals, typically mice or rats, are exposed to the test substance,
The micronucleus test is widely used in regulatory toxicology and environmental monitoring due to its sensitivity,