Microcolumns
Microcolumns are a type of chromatography column that utilizes a very small internal diameter, typically ranging from tens to hundreds of micrometers. This small dimension leads to significantly reduced mobile phase consumption and increased sensitivity compared to conventional packed columns. The stationary phase within a microcolumn is often coated onto the inner wall of the capillary tubing or packed as very small particles.
The primary advantage of microcolumns lies in their ability to achieve high separation efficiency with minimal
Microcolumns are employed in various chromatographic techniques, including high-performance liquid chromatography (HPLC) and gas chromatography (GC).
Despite their advantages, working with microcolumns can present challenges. The small dimensions require specialized instrumentation for