MTHFD2L
MTHFD2L, also known as methylenetetrahydrofolate dehydrogenase, metallopeptidase and formyltetrahydrofolate synthetase 2-like, is a protein-coding gene found in humans. This gene encodes a bifunctional enzyme that plays a role in folate metabolism. Specifically, it exhibits both formyltetrahydrofolate synthetase and methylenetetrahydrofolate dehydrogenase activities. These activities are crucial for the interconversion of folate derivatives, which are essential cofactors in one-carbon metabolism. One-carbon metabolism is a fundamental biochemical pathway involved in the synthesis of nucleotides, amino acids, and other vital biomolecules.
The protein encoded by MTHFD2L is thought to be localized to the mitochondria. Its precise physiological functions