MHCtetramerbindning
MHCtetramerbindning refers to the binding of MHC tetramers to T cells. MHC tetramers are soluble molecules consisting of four MHC class I or class II molecules, each loaded with a specific peptide antigen, linked together by a flexible biotin-streptavidin bridge. This tetrameric structure allows for multivalent binding to the T cell receptor (TCR) on the surface of T lymphocytes.
The primary purpose of MHCtetramerbindning is to visualize and quantify antigen-specific T cells within a population.
MHCtetramerbindning assays are a crucial tool in immunology research and clinical diagnostics. They are widely used
The specificity of MHCtetramerbindning relies on the correct loading of the peptide onto the MHC molecule.