M1reseptorien

M1reseptorien, also known as muscarinic acetylcholine receptor M1, are a type of G protein-coupled receptor that are activated by the neurotransmitter acetylcholine. These receptors are predominantly found in the central nervous system, particularly in the cerebral cortex and hippocampus, and also play a role in the peripheral nervous system, notably in salivary glands. M1 receptors are primarily coupled to the Gq/11 family of G proteins. Upon activation by acetylcholine, they trigger a cascade of intracellular events, including the activation of phospholipase C, leading to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). This, in turn, results in the release of intracellular calcium and the activation of protein kinase C.

In the brain, M1 receptors are involved in a variety of cognitive functions, including learning, memory, attention, and arousal. They are believed to modulate synaptic plasticity and facilitate excitatory neurotransmission. Their presence in the cortex suggests a role in higher-order cognitive processing. In the periphery, activation of M1 receptors in salivary glands stimulates the secretion of saliva. Due to their significant role in cognitive processes, M1 receptors are a target for the development of therapeutic agents for conditions such as Alzheimer's disease and schizophrenia, where cholinergic deficits are implicated. Agonists that activate M1 receptors aim to enhance cognitive function, while antagonists might be used to reduce certain physiological responses.