LoeweAdditivität
LoeweAdditivität, also known as Loewe additivity, is a concept in pharmacology and toxicology that describes the combined effect of two or more substances when they are administered together. The principle is based on the work of the German pharmacologist Karl Loewe, who first described it in the 1920s. Loewe additivity is particularly relevant in the context of drug interactions and the assessment of potential risks associated with the simultaneous use of multiple substances.
The concept of Loewe additivity is often used to evaluate the potential for synergistic or antagonistic effects
Loewe additivity is quantified using the Loewe equation, which compares the combined effect of two substances
The principle of Loewe additivity is widely used in pharmaceutical research and regulatory assessments to predict