Lipokine

Lipokines are a class of signaling molecules derived from adipose tissue. They are a type of adipokine, which refers to any protein secreted by adipocytes. Lipokines are distinct from other adipokines in that they are specifically characterized by their lipophilic nature or their role in lipid metabolism. These molecules are involved in a variety of physiological processes, including energy homeostasis, glucose metabolism, inflammation, and cardiovascular function.

The precise definition and classification of lipokines are still evolving within the scientific community. However, research has identified several candidate molecules that fit the lipokine profile. Examples include certain fatty acid-binding proteins and lipid mediators like prostaglandins and leukotrienes, although these are sometimes categorized separately. The focus on lipokines emphasizes the active role of fat cells not just as energy storage depots but as endocrine organs that communicate with other tissues through secreted factors.

Studies suggest that dysregulation of lipokine production or signaling can contribute to metabolic disorders such as obesity, type 2 diabetes, and cardiovascular disease. Understanding the function and regulation of lipokines is therefore an active area of research with potential implications for the development of new therapeutic strategies for these conditions. Further investigation is ongoing to fully elucidate the diverse roles of lipokines in health and disease.