Leukine

Leukine, also known by its generic name sargramostim, is a recombinant human granulocyte-macrophage colony-stimulating factor (rhu GM-CSF). It is a protein that stimulates the production and maturation of white blood cells, specifically neutrophils and macrophages, in the bone marrow. These white blood cells are crucial components of the immune system, responsible for fighting infection.

Leukine is administered medically to help patients recover their white blood cell counts after certain medical treatments that suppress bone marrow function. This includes its use in chemotherapy and bone marrow transplantation. By stimulating the production of neutrophils and macrophages, Leukine can reduce the risk and duration of infections in individuals with compromised immune systems. It is typically administered via injection, either subcutaneously or intravenously.

The development of Leukine represents a significant advancement in supportive care for cancer patients and others undergoing treatments that affect the bone marrow. Its ability to accelerate the recovery of immune cell populations can significantly improve patient outcomes and quality of life during these challenging periods. Side effects can include bone pain, fever, and rash, among others, and are generally managed by healthcare professionals.