Lenzingins

Lenzingins are a class of organic compounds that are derivatives of the naturally occurring lignan, podophyllotoxin. Podophyllotoxin is a cytotoxic compound found in the roots and rhizomes of plants belonging to the genus Podophyllum. Lenzingins are synthesized from podophyllotoxin and possess potent anticancer properties. Their mechanism of action primarily involves inhibiting tubulin polymerization, which is crucial for the formation of the mitotic spindle during cell division. By disrupting this process, lenzingins prevent cancer cells from proliferating.

The development of lenzingins as therapeutic agents has focused on improving their efficacy and reducing the toxicity associated with podophyllotoxin. Modifications to the podophyllotoxin structure have led to several lenzingin derivatives, some of which have entered clinical trials. These derivatives aim to achieve a better therapeutic index, meaning a wider range between the dose that is effective against cancer and the dose that causes unacceptable side effects. Research into lenzingins continues to explore new structural modifications and delivery methods to enhance their anticancer potential and expand their applicability to various types of cancer.