Kolie

KOlie refers to a family of retroviral sequences found in the genome of various species, particularly mammals. These sequences are remnants of ancient viral infections that became integrated into the host's DNA and were subsequently passed down through generations. KOlie elements are characterized by their LTRs (long terminal repeats) at both ends, which are hallmarks of retroviral integration. They are often referred to as endogenous retroviruses (ERVs) due to their viral origin and presence within the host genome.

The exact function of Kolie elements is not fully understood, and they are generally considered to be non-functional relics. However, some research suggests that they may play a role in gene regulation, either by influencing the expression of nearby genes or by contributing to the overall structure of the genome. Their presence and activity can vary significantly between different species and even between individuals within the same species. Studies of Kolie sequences can provide insights into evolutionary history and the complex interactions between viruses and their hosts over long periods.