Kokonaisbioavailability

Kokonaisbioavailability, also known as total bioavailability, refers to the overall extent and rate at which a substance, typically a drug or nutrient, becomes available to the target tissue or is accessible to the receptor site in the body. It is a crucial concept in pharmacology and nutrition, as it helps determine the effectiveness of a substance once it is administered or consumed.

Bioavailability is influenced by several factors, including the route of administration, the substance's chemical properties, and individual physiological differences. When a substance is administered intravenously, it is assumed to have 100% bioavailability because it directly enters the bloodstream. However, other routes such as oral, topical, or inhaled administration may result in lower bioavailability due to factors like absorption barriers, metabolism, and excretion.

Kokonaisbioavailability can be divided into two main components: absolute bioavailability and relative bioavailability. Absolute bioavailability compares the bioavailability of a substance via a non-intravenous route to that of an intravenous route. Relative bioavailability, on the other hand, compares the bioavailability of a substance from different non-intravenous routes or formulations.

Understanding kokonaisbioavailability is essential for optimizing dosing regimens, developing effective drug delivery systems, and ensuring that nutrients are adequately absorbed. It helps healthcare professionals and researchers make informed decisions about the most effective and safe ways to administer substances to achieve the desired therapeutic or nutritional effects.