KLF5

KLF5, also known as Kruppel-like factor 5, is a transcription factor that plays a crucial role in various biological processes. It belongs to the Sp1-like transcription factor family and is characterized by a DNA-binding domain containing three Cys2-Cys2 zinc finger motifs. KLF5 is widely expressed in many tissues, with particularly high levels found in the colon, skin, and heart.

This transcription factor is involved in regulating a diverse range of cellular functions, including cell proliferation, differentiation, apoptosis, and migration. It achieves these effects by binding to specific DNA sequences and modulating the expression of target genes. KLF5 is known to interact with numerous co-activators and co-repressors, allowing for fine-tuning of gene expression in response to various cellular signals.

In development, KLF5 is essential for the proper formation and function of organs such as the heart and gastrointestinal tract. It also plays a significant role in maintaining tissue homeostasis and repair. Dysregulation of KLF5 has been implicated in the development and progression of various diseases, including cancer. In certain cancers, KLF5 can act as an oncogene, promoting tumor growth and survival by activating genes involved in proliferation and angiogenesis. Conversely, in other contexts, it can exhibit tumor-suppressive properties. Research continues to explore the complex roles of KLF5 in both normal physiology and disease pathogenesis.