Integrinassociated

Integrinassociated refers to proteins and molecules that interact with integrins, a family of cell surface receptors. Integrins play crucial roles in cell adhesion, cell signaling, and cell migration by binding to extracellular matrix proteins and other ligands. The proteins that associate with integrins are diverse and perform various functions, often modulating integrin activity or mediating downstream signaling pathways.

These associated proteins can be categorized based on their location and function. Some are located intracellularly, such as talin, vinculin, and alpha-actinin, which are part of the cytoskeleton and link integrins to actin filaments, thereby stabilizing cell adhesion and transmitting mechanical forces. Other intracellular proteins, like focal adhesion kinase (FAK) and Src family kinases, are recruited to integrin adhesion sites and initiate signaling cascades that regulate cell survival, proliferation, and gene expression.

Extracellularly, associated molecules can include components of the extracellular matrix that bind to integrins, such as fibronectin and collagen. Additionally, some secreted proteins or cell surface molecules can influence integrin function indirectly. The dynamic interplay between integrins and their associated proteins is essential for a wide range of biological processes, including embryonic development, tissue repair, immune responses, and the pathogenesis of diseases like cancer and fibrosis. Understanding these interactions is vital for developing targeted therapies.