Insig2

INSIG2, also known as Insig-2 or insulin gene enhancer binding protein 2, is a protein-coding gene. The INSIG2 gene provides instructions for making a protein that plays a role in regulating lipid metabolism. Specifically, the INSIG2 protein is involved in the endoplasmic reticulum, a cellular organelle responsible for protein and lipid synthesis. It acts as an adapter molecule, interacting with other proteins to control the activity of key enzymes involved in cholesterol and fatty acid synthesis. This regulation is crucial for maintaining cellular homeostasis and responding to nutritional changes.

Mutations in the INSIG2 gene have been associated with various health conditions. Some studies suggest a link between variations in INSIG2 and an increased risk of obesity and type 2 diabetes. These associations are thought to be related to the protein's role in lipid metabolism, where disruptions can lead to abnormal fat accumulation and insulin resistance. Research is ongoing to further understand the precise mechanisms by which INSIG2 influences these metabolic disorders and to explore its potential as a therapeutic target.