Insideoutsignaalointi
Insideoutsignaalointi, or inside-out signaling, is a form of cellular signaling in which intracellular cues regulate the activity or affinity of transmembrane receptors, notably integrins, thereby increasing their binding to extracellular ligands. This is in contrast to outside-in signaling, where ligand binding initiates intracellular responses. The concept is widely used in cell biology to describe how cells control adhesion and signaling through receptor activation from within.
Mechanism: In integrins, intracellular signals driven by receptors such as G protein-coupled receptors or chemokine receptors
Examples and roles: In platelets, inside-out signaling activates αIIbβ3 (GPIIb/IIIa) to bind fibrinogen and von Willebrand
Clinical relevance: Defects in inside-out signaling can lead to bleeding disorders or immune dysfunction. For example,
Research and scope: Inside-out signaling remains a central concept in integrin biology and cell adhesion. While