InPHBT

InPHBT stands for Intramolecular Photocyclization of Hindered Biaryls with a Thiol group. It is a chemical reaction that involves the formation of a new ring structure within a molecule. Specifically, this reaction utilizes a hindered biaryl compound, meaning two aromatic rings are directly connected but are sterically hindered from rotating freely. A thiol group (-SH) is also present in the molecule, playing a crucial role in the reaction mechanism.

The process is initiated by light, or photochemistry, which triggers the cyclization. The hindered biaryl system undergoes a photoinduced reaction, leading to the formation of a new bond between parts of the molecule. The presence of the thiol group is essential for this process, often acting as a catalyst or participating directly in the bond formation. This results in the creation of a fused ring system, where the original biaryl structure is incorporated into a larger, cyclic framework.

InPHBT reactions have been explored for their synthetic utility in creating complex organic molecules. The ability to form new ring systems under mild, light-induced conditions makes it an attractive method for constructing molecular architectures that might be difficult to achieve through traditional synthetic routes. Research in this area often focuses on understanding the detailed mechanism, optimizing reaction conditions, and applying it to the synthesis of various target compounds.