Immünodepozitler

Immünodepozitler, also known as immune deposits, are complexes of antigens and antibodies that accumulate in tissues. These deposits can be formed when the immune system mistakenly identifies self-antigens or foreign substances as threats. The binding of antibodies to these antigens creates immune complexes, which can then be deposited in various organs and tissues, such as the kidneys, skin, joints, and blood vessels.

The deposition of immune complexes can trigger inflammatory responses. The complement system, a part of the innate immune system, can be activated by these complexes, leading to the release of inflammatory mediators and the recruitment of immune cells. This inflammation can damage the surrounding tissues and organs, leading to various pathological conditions.

The presence of immune deposits is a hallmark of several autoimmune diseases, including lupus nephritis, rheumatoid arthritis, and vasculitis. Diagnosis often involves tissue biopsies where specific staining techniques, such as immunofluorescence microscopy, are used to detect the presence and type of immune deposits. The location and composition of these deposits can help determine the underlying disease and guide treatment. Treatment strategies often focus on suppressing the immune response to reduce the formation and deposition of these complexes.