Immunkomplexvaskuliter

Immunkomplexvaskulitis, also known as immune complex vasculitis, is a group of inflammatory disorders characterized by the deposition of immune complexes in the walls of blood vessels. These immune complexes are typically composed of antigens and antibodies, which can form in response to infections, autoimmune diseases, or other triggers. The deposition of these complexes in the vessel walls leads to inflammation, damage, and potential occlusion of the vessels, which can result in various clinical manifestations.

The clinical presentation of immunkomplexvaskulitis can vary widely depending on the specific type and location of the affected vessels. Common symptoms include fever, fatigue, weight loss, and organ-specific manifestations such as arthritis, glomerulonephritis, and peripheral neuropathy. The diagnosis of immunkomplexvaskulitis often relies on a combination of clinical evaluation, laboratory tests, and imaging studies. Laboratory findings may include elevated levels of C-reactive protein, antinuclear antibodies, and complement components.

Treatment of immunkomplexvaskulitis aims to reduce inflammation, control the underlying autoimmune process, and manage symptoms. Common therapeutic approaches include corticosteroids, immunosuppressants, and disease-modifying antirheumatic drugs. In some cases, plasmapheresis may be used to remove circulating immune complexes. The prognosis varies depending on the severity of the disease and the effectiveness of treatment. Early diagnosis and prompt initiation of appropriate therapy can significantly improve outcomes and quality of life for patients with immunkomplexvaskulitis.