Iminederived

Iminederived is a term used in organic chemistry to describe compounds that are formed through the reaction of an amine with a carbonyl compound, typically an aldehyde or a ketone, followed by dehydration. This reaction, known as imine formation or Schiff base formation, results in the creation of a carbon-nitrogen double bond (C=N). The general structure of an imine is R1R2C=NR3, where R1 and R2 can be hydrogen or alkyl/aryl groups, and R3 is an alkyl or aryl group.

The process of imine formation is reversible and often catalyzed by acid. The initial step involves the nucleophilic attack of the amine nitrogen on the electrophilic carbon of the carbonyl group, forming a tetrahedral intermediate called a hemiaminal. Subsequently, proton transfer and elimination of water lead to the formation of the imine. Iminederived compounds are important intermediates in many organic syntheses. They can be reduced to form secondary amines, or they can undergo further reactions such as nucleophilic addition across the C=N bond. The stability of imines varies depending on the substituents and reaction conditions. They are widely encountered in biological systems, for example, in the formation of pyridoxal phosphate (PLP) dependent enzymes.