IL28RA
IL28RA, also known as interferon lambda receptor 1 (IFNLR1), is a protein encoded by the IL28RA gene in humans. It is a key component of the receptor complex for Type III interferons, which include interferon lambda (IFN-λ) subtypes. This receptor complex is primarily involved in mediating antiviral and immunomodulatory responses in epithelial cells and certain immune cells.
IL28RA forms a heterodimer with IL10RB (interleukin 10 receptor beta), creating the functional receptor for IFN-λ.
The expression of IL28RA is tissue-specific, predominantly found on epithelial surfaces such as the respiratory and
IL28RA has garnered interest in the context of viral diseases, including hepatitis C virus (HCV) infection,
Understanding IL28RA’s function contributes to insights into innate immunity and the development of antiviral therapies, particularly