IL28R1

The IL28R1 gene, also known as the interferon lambda receptor 1 gene, encodes a protein that serves as a receptor for the interferon-lambda (IFN-λ) family of cytokines. These cytokines are important in the immune system's response to viral infections and play a role in regulating inflammatory processes. The protein produced by IL28R1 is a type II transmembrane protein that associates with another receptor subunit, IL10RB, to form a functional receptor complex. This complex is primarily expressed on epithelial cells, particularly those in the liver, lungs, and gut. Upon binding of IFN-λ cytokines, the receptor complex signals intracellularly, leading to the activation of the JAK-STAT pathway. This activation results in the induction of a range of interferon-stimulated genes that have antiviral and immunomodulatory effects. Variations in the IL28R1 gene have been associated with differences in susceptibility and response to certain viral infections, such as hepatitis C virus (HCV). Research into IL28R1 continues to explore its precise role in innate immunity and its potential therapeutic implications in infectious diseases and other inflammatory conditions.