IL23driven
IL23driven refers to inflammatory processes that are predominantly powered by the cytokine interleukin-23 (IL-23). IL-23 is produced by activated antigen-presenting cells and functions as a heterodimer composed of a p19 subunit and a p40 subunit that it shares with IL-12. The IL-23 receptor is expressed on various immune cells, including T helper 17 (Th17) cells and certain innate lymphoid cells, enabling IL-23 to influence both adaptive and innate immune responses.
The central mechanism of IL-23–driven inflammation involves the expansion, maintenance, and stabilization of Th17 cells, which
IL-23–driven pathology is implicated in several autoimmune and inflammatory diseases. Notable examples include psoriasis, psoriatic arthritis,