IL13RA1

IL13RA1, also known as interleukin 13 receptor alpha 1, is a protein that in humans is encoded by the IL13RA1 gene. This gene belongs to the interleukin 13 receptor family and is involved in the regulation of immune responses and inflammation. It is expressed on the surface of various immune cells, including mast cells, basophils, and eosinophils, where it plays a crucial role in mediating the effects of interleukin 13 (IL-13).

IL13RA1 forms a heterodimer with the common gamma chain (IL13RA2) to create a functional receptor for IL-13. This receptor is primarily expressed on the surface of mast cells and basophils, where it is involved in the activation of these cells and the subsequent release of mediators such as histamine, leukotrienes, and prostaglandins. These mediators contribute to allergic responses, inflammation, and tissue remodeling.

The IL13RA1 gene is located on chromosome 5 in humans. Mutations in this gene have been associated with various immune-related disorders, including asthma, atopic dermatitis, and allergic rhinitis. These mutations can affect the function of the IL-13 receptor, leading to altered immune responses and increased susceptibility to allergic reactions.

IL13RA1 is a key player in the complex network of immune signaling pathways. Its regulation is important for maintaining immune homeostasis and preventing excessive inflammation. Understanding the function of IL13RA1 and its associated gene provides insights into the pathogenesis of immune-related diseases and may lead to the development of targeted therapies for these conditions.