IL13R2

IL13R2, also known as interleukin-13 receptor subunit alpha-2, is a protein encoded by the IL13RA2 gene in humans. It is a component of the interleukin-13 receptor complex. While the IL-13 receptor is primarily composed of IL13RA1 and IL4R1, IL13RA2 forms a high-affinity binding site for interleukin-13 (IL-13). This binding is independent of IL-4 receptor alpha (IL4RA). IL13R2 is expressed in various tissues, including the brain, lungs, and placenta. Its expression is particularly notable in astrocytes and in certain pathological conditions. The precise biological function of IL13R2 is still under investigation. However, it is believed to play a role in modulating IL-13 signaling and may act as a decoy receptor, sequestering IL-13 from its functional receptors. Dysregulation of IL13RA2 has been implicated in inflammatory diseases and certain cancers, particularly glioblastoma. In glioblastoma, IL13RA2 is often overexpressed and has been explored as a therapeutic target for drug delivery.