IL13R1IL4R

IL13R1IL4R refers to the interleukin-13 receptor alpha 1 and interleukin-4 receptor alpha chains. These two proteins form a critical component of the receptor complex for the cytokines interleukin-4 (IL-4) and interleukin-13 (IL-13). While IL-4Rα alone can bind IL-4, the formation of a heteromeric complex with IL-13Rα1 is required for high-affinity binding and signaling of IL-13. This complex also plays a role in the signaling of IL-4. The IL-13Rα1 subunit, also known as IL-13RA1 or CRTH2, is a transmembrane protein that contributes to the specificity of IL-13 binding. The IL-4Rα subunit, or IL4R, is also a transmembrane protein and is central to the signaling pathways activated by both IL-4 and IL-13. Upon binding of their respective cytokines, the receptor complex initiates intracellular signaling cascades, primarily through the JAK-STAT pathway. This signaling is crucial for a variety of biological processes, including immune responses, B cell differentiation, and T helper cell polarization, particularly towards the Th2 phenotype. Dysregulation of IL-4 and IL-13 signaling, involving these receptor subunits, is implicated in allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis. Consequently, IL13R1IL4R has become a target for therapeutic interventions aimed at modulating immune responses in these conditions.