IKKs
IκB kinases, abbreviated IKKs, are a family of serine/threonine kinases that regulate the NF-κB signaling pathway. In the canonical pathway, the IKK complex is a heterotrimer composed of two catalytic subunits, IKKα and IKKβ, and a regulatory subunit, IKKγ, also known as NEMO. A related group of kinases, TBK1 and IKKε, are IKK-related kinases but are typically distinguished from the canonical IKK complex.
Activation and function: In response to stimuli such as proinflammatory cytokines (TNF, IL-1), lipopolysaccharide, or cellular
Regulation and clinical relevance: IKK activity is tightly regulated by deubiquitinases and feedback mechanisms, including resynthesis
Structure and notes: IKKα and IKKβ contain kinase domains in their C-termini, with NEMO facilitating complex