IGFsignaler

IGFsignaler is a proposed component of the insulin-like growth factor (IGF) signaling network. It is described in some scientific reports as a cytoplasmic adaptor protein that becomes associated with the activated IGF1 receptor and serves to propagate signals to downstream pathways, notably PI3K-AKT and MAPK cascades. By bridging receptor activation to intracellular effectors, IGFsignaler is thought to influence cell growth, metabolism, survival, and differentiation in a context-dependent manner.

Structure and expression: IGFsignaler is predicted to contain modular protein interaction domains that facilitate assembly of signaling complexes. It is primarily cytoplasmic, with conditions that may promote nucleocytoplasmic shuttling. Expression has been reported in several tissues and is regulated by growth factors, nutrients, and hormonal status.

Functional roles: In cells where IGF signaling is active, IGFsignaler can modulate the amplitude and duration of signaling, affecting proliferation and anti-apoptotic responses. It may also participate in cross-talk with other signaling pathways.

Regulation and interactions: Post-translational modifications such as phosphorylation can modulate IGFsignaler activity. Reported protein interactions include IGF1 receptor, adaptor proteins like IRS family members, SHC, Grb2, and components of PI3K and MAPK pathways.

Clinical relevance: Altered levels or activity of IGFsignaler have been described in some cancers and metabolic diseases, suggesting potential as a biomarker or target, though the evidence is variable and research is ongoing. Its precise role can differ among species and tissue types.

See also: IGF signaling, IGF1 receptor, IRS proteins, PI3K-AKT, MAPK.

Notes: The term IGFsignaler has appeared in a subset of literature; as a non-standardized designation, definitions may vary between studies.