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HOXGencluster

HOXGencluster is a bioinformatics resource that curates and analyzes HOX gene clusters across diverse species. It collects genomic coordinates, gene content, transcriptional orientation, and regulatory context for HOX clusters to support comparative genomics and evolutionary studies.

Scope and data sources: The repository covers representative vertebrates and invertebrates with published HOX cluster annotations.

Data model and analyses: HOXGencluster uses a standardized schema to store cluster boundaries, gene content, and

Access and features: Users can search by gene symbol, species, chromosomal location, or cluster ID. Visualization

Development and use: HOXGencluster is maintained by a collaborative team of genomics researchers and is supported

See also: HOX gene, homeobox, gene cluster, synteny, comparative genomics.

Data
are
drawn
from
genome
assemblies
in
public
databases,
curated
literature,
and
community
submissions.
Each
cluster
entry
includes
gene
order,
strand
orientation,
intergenic
distances,
and
boundaries
that
define
the
cluster
region.
Regulatory
elements
such
as
enhancers
and
promoters
associated
with
HOX
genes,
when
available,
are
annotated
and
linked
to
experimental
evidence
or
high-confidence
predictions.
orthology
relationships.
Synteny
maps
and
multi-species
alignments
support
detection
of
rearrangements
and
duplications,
including
cluster
duplications
characteristic
of
some
lineages.
The
platform
provides
tools
for
phylogenetic
analysis
of
HOX
clusters
and
visualization
of
cluster
evolution
across
taxa.
tools
include
interactive
synteny
browsers,
cluster
alignments,
and
gene
order
viewers.
Exports
are
available
in
common
formats
(CSV,
GFF3,
FASTA),
and
an
API
enables
programmatic
access
to
data.
The
project
emphasizes
data
provenance,
with
citations
to
source
publications
and
versioned
releases.
by
community
submissions.
It
is
used
to
study
HOX
cluster
conservation
and
divergence,
the
impact
of
genomic
rearrangements
on
gene
regulation,
and
the
annotation
of
HOX
genes
in
newly
sequenced
genomes.