HOXAHOXD
HOXA and HOXD are two homeobox-containing gene clusters that are crucial in the development and patterning of various tissues and organs in multicellular organisms, particularly in humans and other vertebrates. These genes are responsible for regulating morphogenesis, or the process of organ formation and cell differentiation, during embryonic development.
The HOXA cluster is comprised of nine gene members: HOXA1 to HOXA9;
HOXA2), each of which encodes for a homeodomain protein, a type of transcription factor that binds to
HOXD genes are located on the short arm of chromosome 2, where they are clustered together in
HOXA and HOXD genes are involved in various developmental processes, such as limb morphogenesis, neural tube