HLX1

HLX1 is a gene that encodes a protein known as homeobox L1. This protein belongs to the HOX family of transcription factors, which are crucial for the proper development of an organism, particularly in establishing the anterior-posterior axis during embryogenesis. HOX proteins act by regulating the expression of other genes, thereby controlling cell differentiation and the formation of specific body parts. The precise role of HLX1 in human development is still an area of active research, but it is thought to be involved in the development of the hematopoietic system, the nervous system, and potentially other tissues. Aberrant expression or mutations in HOX genes, including HLX1, have been linked to various developmental disorders and certain types of cancer. Studies have investigated HLX1's involvement in conditions like acute myeloid leukemia (AML) and neuroblastoma, suggesting it may function as an oncogene or tumor suppressor depending on the cellular context. Understanding the regulatory mechanisms and downstream targets of HLX1 is important for deciphering its contribution to both normal development and disease. Research efforts continue to explore its potential as a therapeutic target.