HLADQB10602

HLADQB10602 is a designation used in immunogenetics to refer to the HLA-DQB1*06:02 allele, a variant of the HLA-DQB1 gene that encodes the beta chain of the HLA-DQ molecule, a component of the major histocompatibility complex class II. In many databases, HLADQB10602 identifies the DQB1*06:02 allele, which is typically inherited as part of the HLA-DQA1-DQB1 haplotype on chromosome 6p21.3.

Molecularly, HLA-DQ molecules form heterodimers consisting of an alpha chain (encoded by HLA-DQA1) and a beta chain (encoded by HLA-DQB1). These molecules present peptide antigens to CD4+ T cells, playing a central role in initiating and regulating adaptive immune responses.

Population distribution of DQB1*06:02 varies by ethnicity, but the allele is found across diverse populations. Its presence is clinically significant because it is strongly associated with narcolepsy with cataplexy, particularly when paired with the DQA1*01:02 allele in the DQA1-DQB1 haplotype. While this haplotype is a major genetic risk factor for narcolepsy with cataplexy, the allele alone is not diagnostic. Conversely, DQB1*06:02-containing haplotypes have been linked to reduced risk of type 1 diabetes in some contexts, though the overall risk profile depends on the accompanying haplotypic background.

In research and clinical genetics, HLADQB10602 serves as a codified reference for data annotation and allele-specific studies within HLA typing and disease association analyses. It is used to interpret immunogenetic risk patterns and to inform broader investigations into HLA-related diseases.