H2AK119ub
Histone H2A lysine 119 ubiquitination, referred to as H2AK119ub1, is a post-translational modification in which a single ubiquitin molecule is attached to lysine 119 of histone H2A. In mammals, this mark is deposited primarily by the Polycomb Repressive Complex 1 (PRC1).
PRC1 is a family of complexes that include the E3 ubiquitin ligase subunits RING1A or RING1B and
Genomically, H2AK119ub1 is enriched at promoters of developmentally regulated genes targeted by Polycomb and often co-localizes
Dynamic regulation occurs through deubiquitination by enzymes such as BAP1, part of the PR-DUB complex, which
Functionally, H2AK119ub1 is important for proper development; disruption of PRC1 activity or misregulation of this mark