H2ABbd

H2ABbd is a short tandem repeat (STR) DNA profile used in forensic science. It refers to a specific locus on the human genome that exhibits significant variation between individuals. This variation arises from the differing number of times a particular DNA sequence, the "repeat unit," is present at this locus. The sequence typically consists of two base pairs, hence the "H2" designation in its name, indicating a dinucleotide repeat. The "ABbd" part refers to the specific sequence of the repeat unit, which in this case is Adenine and Guanine followed by a variant form.

Forensic scientists analyze the length of this STR, which is directly proportional to the number of repeat units present. By comparing the lengths of the STR at the H2ABbd locus between a crime scene sample and a suspect's DNA, investigators can determine if they match. A match at H2ABbd, along with matches at other STR loci, significantly strengthens the evidence linking an individual to a crime. Conversely, a mismatch at this locus can exclude an individual as a potential source of the DNA. The high degree of variability at H2ABbd makes it a valuable component of DNA profiling systems worldwide. Its inclusion in standard forensic STR kits contributes to the power and reliability of DNA analysis in criminal investigations.