Gottronin
Gottronin is a synthetic compound that has gained attention for its potential therapeutic applications, particularly in the field of oncology. It is a derivative of the natural compound gotuic acid, which is found in the leaves of the Gotu Kola plant. Gottronin is believed to have various biological activities, including anti-inflammatory, antioxidant, and neuroprotective properties. Its primary mechanism of action involves the inhibition of the enzyme cyclooxygenase-2 (COX-2), which is involved in the production of prostaglandins, particularly prostaglandin E2 (PGE2). PGE2 is a key mediator of inflammation and has been implicated in the progression of various diseases, including cancer.
In oncology, Gottronin has been studied for its potential to inhibit the growth and spread of cancer
However, the clinical development of Gottronin has been limited by its poor solubility and bioavailability. Efforts