GnRHpulsbehandling

GnRHpulsbehandling, also known as pulsatile gonadotropin-releasing hormone therapy, is a medical treatment used to stimulate ovulation in individuals with certain types of infertility. This therapy mimics the natural pulsatile release of gonadotropin-releasing hormone (GnRH) from the hypothalamus in the brain. GnRH is a decapeptide hormone that travels to the pituitary gland and stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones, in turn, are crucial for the development and release of eggs from the ovaries.

The treatment involves administering synthetic GnRH intravenously or subcutaneously in small, regular pulses. This delivery method is essential because continuous administration of GnRH or its analogs can desensitize the pituitary gland, leading to suppression of FSH and LH release, which is counterproductive for ovulation induction. GnRH pulsatile therapy is typically prescribed for women with hypothalamic amenorrhea, a condition characterized by the absence of menstruation due to insufficient GnRH secretion, and for those with polycystic ovary syndrome (PCOS) who have not responded to other ovulation induction methods.

The administration is usually done using a portable pump that delivers the GnRH every 60 to 120 minutes. The dosage and frequency are carefully monitored and adjusted by a fertility specialist. Successful ovulation is typically confirmed by hormonal monitoring and ultrasound scans showing follicle development. If ovulation occurs, timed intercourse or intrauterine insemination (IUI) is usually recommended. GnRH pulsatile therapy is a specialized treatment and requires close medical supervision.