Glukuronide
Glucuronide (also spelled glukuronide) is a compound in which glucuronic acid is covalently bound to another molecule through a glycosidic bond. Glucuronidation is a major phase II metabolic reaction that increases the water solubility of lipophilic substances, promoting their excretion in urine or bile.
The reaction is catalyzed by UDP-glucuronosyltransferases (UGTs), a family of enzymes located mainly in the endoplasmic
Endogenous substrates such as bilirubin, steroid and thyroid hormones, bile acids, and fatty acids are natural
Clinical and pharmacological relevance: genetic variation in UGT enzymes and drug interactions can affect glucuronide formation