GcFc

GcFc is an acronym that appears in a limited range of scientific literature and does not have a single, universally accepted definition. Its meaning is highly context-dependent and can vary between disciplines, studies, and even between papers from the same field. In general, readers should look for a precise definition within the source article, such as in the methods, figure legends, or a dedicated terminology section.

In protein engineering and immunology contexts, GcFc is sometimes used to denote a conceptual or engineered fusion that links a Gc-related domain (often referencing Gc globulin, also known as vitamin D–binding protein) to an Fc fragment of an antibody. The intended purpose of such constructs would be to explore how Fc-mediated effector functions, half-life extension, or receptor interactions interact with Gc-derived properties. However, the exact design, sequence composition, and functional interpretation of GcFc can differ across studies, and the term is not standardized.

Because GcFc is not a standardized term, it can also appear as a shorthand label in data tables or figures to indicate combined Gc-related and Fc-related assays without implying a physical fusion. Researchers encountering the term should verify its definition in the specific work and consider related concepts such as Gc globulin, the Fc region of immunoglobulins, Fc fusion proteins, and GcMAF (Gc protein–derived macrophage activating factor) when interpreting context.

See also: Gc globulin, vitamin D–binding protein, Fc region, Fc fusion proteins, GcMAF.