GTExi

The Genotype-Tissue Expression (GTEx) project is a large-scale, publicly funded initiative aimed at understanding the relationship between genetic variation and gene expression in various human tissues. Launched in 2010, GTEx collects tissue samples from deceased donors across a wide range of ages and ancestries. Researchers then analyze these samples to measure gene expression levels and identify genetic variants, such as single nucleotide polymorphisms (SNPs).

The core goal of GTEx is to create a comprehensive resource that maps genetic variants to their effects on gene activity in different parts of the body. This helps scientists understand how common genetic variations influence disease risk and other traits. By examining gene expression across hundreds of tissue types, GTEx can reveal how genetic regulation differs across the human body.

The data generated by GTEx, including gene expression profiles and genotype information, is made publicly available through a dedicated portal. This resource is invaluable for researchers in genomics, genetics, and a variety of biomedical fields. It enables studies on the functional consequences of genetic variation, the identification of novel disease-associated genes, and the development of more personalized medicine approaches. The project has been instrumental in advancing our understanding of human biology and the genetic underpinnings of health and disease.