GPCRid

GPCRid is a standardized identifier system designed to uniquely label G protein-coupled receptors (GPCRs) across biological databases and resources. It provides a persistent code for each receptor entry to enable unambiguous data integration, cross-referencing, and retrieval of GPCR-related information from diverse sources.

A GPCRid entry typically comprises a stable identifier, an optional version or revision tag, and links to complementary data such as gene symbols, UniProt accessions, PDB structures, and curated functional annotations. The system supports synonyms and historical identifiers to maintain traceability as nomenclature or classifications evolve. It is designed to support programmatic access through APIs or data dumps, facilitating batch queries, mapping between resources, and integration into analysis pipelines.

Scope and coverage commonly include canonical GPCRs across classes A, B, C, and others, with emphasis on human receptors while extending to model organisms. Limitations may arise for orphan receptors or entries lacking structural data, and mappings can change as new data are added or updated. Versioning helps document revisions to receptor annotations, sequence data, or cross-references.

In practice, GPCRid aids data curation, literature mining, and comparative analyses by providing a stable, cross-resource identifier. Researchers use GPCRid to disambiguate entries, track revisions, and combine datasets from resources such as GPCRdb, UniProt, PDB, and IUPHAR/BPS Guide to Pharmacology, promoting interoperability and reproducibility in GPCR research.