GPCR34

GPCR34 is a provisional designation for a hypothetical G protein-coupled receptor. While not yet formally named or extensively characterized, it is often referred to as GPR34 or sometimes PUMA-G. Its existence is inferred from genomic data, suggesting it may encode a functional receptor. Like other G protein-coupled receptors, GPCR34 is predicted to be a transmembrane protein with seven helices that, upon binding to an endogenous ligand, initiates intracellular signaling pathways through the activation of G proteins. The specific ligands and physiological roles of GPCR34 remain largely unknown. Research into this receptor is ongoing, with efforts focused on identifying its natural agonists, antagonists, and its potential involvement in various biological processes and diseases. Understanding GPCR34's function could open new avenues for therapeutic interventions.