GNG8

GNG8 is a gene that encodes a protein involved in cell growth and division. This protein belongs to the guanine nucleotide exchange factor family, which plays a crucial role in regulating the activity of small GTPases, particularly those in the Rho family. These Rho GTPases are key players in a variety of cellular processes, including the organization of the actin cytoskeleton, cell motility, and signal transduction pathways that control cell proliferation and differentiation.

The GNG8 protein acts by promoting the exchange of GDP for GTP on its target GTPases, thereby activating them. Dysregulation of GNG8 expression or function has been implicated in various diseases, including certain types of cancer. Alterations in GNG8 can lead to uncontrolled cell growth and contribute to tumor development and progression. Research into GNG8's precise molecular mechanisms and its role in disease is ongoing, aiming to identify potential therapeutic targets for conditions associated with its dysfunction.