GNG2s

GNG2s, also known as G protein-coupled receptor 2 (GPR2), are a family of G protein-coupled receptors (GPCRs) that play a significant role in various physiological processes. These receptors are characterized by their ability to bind to a wide range of ligands, including peptides, proteins, and small molecules. GNG2s are expressed in various tissues and cell types, including the brain, heart, and immune cells.

The GNG2 family consists of two main subtypes, GNG2-1 and GNG2-2, which are encoded by different genes. These subtypes share a high degree of sequence similarity but exhibit distinct tissue distribution and functional properties. GNG2-1 is primarily expressed in the brain, while GNG2-2 is more widely distributed, with expression in the heart, immune cells, and other tissues.

GNG2s are involved in a variety of biological processes, including neurotransmission, immune response, and cardiovascular function. They act as receptors for several endogenous ligands, such as neuropeptides and cytokines, and their activation leads to the activation of G proteins, which in turn regulate intracellular signaling pathways. The specific functions of GNG2s in different tissues and cell types are still an active area of research, and their potential as therapeutic targets for various diseases is being explored.