Follistatinrelated

Follistatin-related gene, also known as FLRG, is a protein-coding gene found in humans and other mammals. It is a member of the follistatin gene family, which also includes follistatin (FS). FLRG encodes a secreted protein that shares structural similarities with follistatin, particularly in its cysteine-rich domains. However, FLRG has distinct functional properties.

The FLRG protein is known to interact with activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily. Like follistatin, FLRG can bind to activins and inhibit their signaling pathways. This inhibitory action is crucial in regulating various biological processes, including cell growth, differentiation, and apoptosis.

Research has indicated that FLRG plays a role in embryonic development and tissue homeostasis. Its expression has been observed in various tissues, including the brain, muscle, and reproductive organs. Aberrant expression or mutations in the FLRG gene have been implicated in certain developmental disorders and diseases, although the exact mechanisms are still under investigation. Understanding the precise functions of FLRG is an ongoing area of research in molecular biology and developmental biology.