Fibrinoidalna

Fibrinoidalna refers to a substance that resembles fibrin, a protein that plays a crucial role in blood clotting. Fibrinoid material is not true fibrin but shares some of its physical and tinctorial characteristics. It is typically eosinophilic, meaning it stains pink with eosin, a common stain used in histology. Fibrinoid material is often found deposited in the walls of blood vessels and in connective tissues. Its presence is usually indicative of tissue damage and inflammation. The exact composition of fibrinoid can vary, but it often includes plasma proteins such as fibrinogen, immunoglobulins, and complement components, along with cellular debris. This deposition can occur in various pathological conditions, including autoimmune diseases like lupus erythematosus, where it is a characteristic finding in the glomerular basement membranes of the kidneys, and in certain types of vasculitis. The accumulation of fibrinoid material can lead to thickening and narrowing of blood vessels, potentially impairing blood flow and causing further tissue damage. Histopathological examination is essential for identifying and characterizing fibrinoid deposits.