FcRIIIACD16a

FcRIIIACD16A is a gene located on chromosome 16, specifically at position 16q24.3. It encodes for the Fc receptor IIIA (CD16A), a member of the immunoglobulin superfamily. CD16A is primarily expressed on the surface of natural killer (NK) cells and plays a crucial role in their immune function. The receptor binds to the Fc region of immunoglobulin G (IgG) antibodies, facilitating the killing of infected cells and the regulation of immune responses. Variations in the FcRIIIACD16A gene have been associated with differences in NK cell activity and susceptibility to certain infections. Additionally, polymorphisms in this gene have been linked to autoimmune disorders and cancer progression. Understanding the genetic basis of CD16A expression and function is essential for developing targeted therapies and improving immune-based treatments.