FLcrF

FLcrF, also known as Feline Leukemia Virus Subgroup C Receptor F, is a protein that plays a crucial role in the immune response of cats. It is a member of the immunoglobulin superfamily and is expressed on the surface of various immune cells, including T cells, B cells, and natural killer cells. FLcrF serves as a receptor for the Feline Leukemia Virus (FeLV), a retrovirus that can cause leukemia and other immune-related diseases in cats.

The FLcrF protein is encoded by the FLCR gene, which is located on chromosome 1 of the feline genome. This gene is highly polymorphic, with numerous allelic variants that can influence the susceptibility of cats to FeLV infection. Some allelic variants of FLCR are associated with increased resistance to FeLV, while others may confer susceptibility.

FLcrF is involved in the early stages of FeLV infection, binding to the viral envelope glycoprotein gp70 and facilitating viral entry into host cells. This interaction is essential for the establishment of persistent FeLV infection, which can lead to the development of FeLV-associated diseases. The study of FLcrF and its interaction with FeLV has provided valuable insights into the pathogenesis of FeLV infection and has contributed to the development of diagnostic tools and therapeutic strategies for managing this important feline pathogen.