FGnucleoporines
FGnucleoporins are a specialized class of proteins found within the nuclear pore complex (NPC) of eukaryotic cells. The NPC is a large protein structure that spans the nuclear envelope, regulating the transport of molecules between the nucleus and the cytoplasm. FGnucleoporins are characterized by the presence of multiple phenylalanine-glycine (FG) repeats within their amino acid sequences. These FG repeats are crucial for the function of the NPC.
The FG-rich domains of these proteins form a mesh-like barrier within the central channel of the NPC.
The precise arrangement and interactions of FGnucleoporins within the NPC create a selective barrier that ensures